Manage disease risk and weight variation with arrival metaphylaxis | Beef Magazine

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Industry Voice by Elanco | Jul 20, 2018

To effectively mitigate bovine respiratory disease (BRD) with metaphylactic program, it is critical to evaluate both the potential risk of disease and weight variation of the cattle in order to choose the right dosage. 

Micotil® (tilmicosin injection) Flex Does provides a dose range of 1.5 to 3 mL/cwt, meaning you can adjust your treatment dose to best match the needs of your cattle. 

"Factors such as unknown origin and vaccination history, commingling, adverse weather and plane of nutrition should all be considered when determining the most appropriate metaphylactic dosage," says Jacob Hagenmaier, D.V.M., Ph.D., Elanco technical consultant. "As more risk factors come into play, the more a higher dose may be warranted."

With over 25 years of proven results and use in over 100 million cattle, Micotil is the only macrolide for the BRD market approved with flexible dose range. This allows feedyards to not only adjust dose based on risk, but also to account for weight variation within a group of cattle. 

Elanco conducted two flex dose studies – one in Texas1 and the other in Colorado2 – comparing the efficacy of 3 vs. 1.5 mL/cwt dosage (20mg/kg and 10 mg/kg, respectively).

According to Hagenmaier, when combined, the findings of these studies are a good example of how an increased dose can be beneficial in certain groups of cattle where there is a higher risk of BRD. 

"Of these two studies, the BRD challenge was greater in the Texas study, based on the mortality levels observed. This is also the study where the 3.0 mL/cwt Micotil dose resulted in lower BRD pull rates compared to the low dose," he says. "But regardless of site and dose, BRD pull rates were decreased for all cattle that received Micotil, compared to the negative control."

Cattle receiving Micotil metaphylaxis also delivered higher net returns per head at closeout in the Texas study. There was a $126.02 and $86.60 advantage for cattle given 3.0 or 1.5 mL/cwt Micotil compared to non-treated controls, respectively.1

To learn more about how Micotil can fit into your customers' protocols, talk to your Elanco sales representative or technical consultant. 

Micotil is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni, and for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica. 

Before using this product, it is important to read the entire product insert, including the boxed human warning.

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Injection of this drug in humans has been associated with fatalities. Keep out of reach of children. Do not use in automatically powered syringes. Exercise extreme caution to avoid accidental self-injection. In case of human injection, consult a physician immediately and apply ice or cold pack to injection site while avoiding direct contact with the skin. Avoid contact with eyes. Always use proper drug handling and use of all injectable products prior to administration. For use in cattle or sheep only. Inject subcutaneously. Injection of this antibiotic has been shown to be fatal in swine and non-human primates, and may be fatal in horses and goats. Do not use in lambs less than 15 kg in weight. Do not use in female dairy cattle 20 months of age or older. Use in lactating dairy cattle or sheep may cause milk residues. The following adverse reactions have been reported: in cattle: injection site swelling and inflammation, lameness, collapse, anaphylaxis/anaphylactoid reactions, decreased food and water consumption, and death; in sheep: dyspnea and death. Micotil has a pre-slaughter withdrawal time of 42 days. 

Elanco supports the use of shared class antibiotics for therapeutic uses while under the oversight of a veterinarian. More details on Elanco's Antibiotic, Welfare and Sustainability Policies can be found on 

1Elanco Animal Health. Data on file. 2Elanco Animal Health. Data on file. 

Micotil, Alanco and the diagonal bar logo are trademarks of Elanco or its affiliates. ©2018 Elanco or its affiliates. pghlth 10876-1 USBBUMIC00162

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